Recent Advances in Transition-Metal-Catalyzed C–H Functionalization Reactions Involving Aza/Oxabicyclic Alkenes

Abstract Bicyclic alkenes, including oxa- and azabicyclic readily undergo activation with facial selectivity in the presence of transition-metal complexes. This is due to intrinsic angle strain on carbon–carbon double bonds such unsymmetrical bicyclic systems. During past decades considerable progress has been made area ring opening strained rings by employing concept C–H activation. short review comprehensively compiles various bond assisted reactions viz., ring-opening reactions, hydroarylation, annulation reactions. 1 Introduction 2 Reactions Heterobicyclic Ring Systems 2.1 Ring-Opening Oxa- Azabenzonorbornadienes 2.1.1 Using 7-Oxabenzonorbornadienes 2.1.2 7-Azabenzonorbornadienes 2.2 Hydroarylation 2.3 Annulation 2.4 Other 3 Conclusion